Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction.

@article{Bers2014CardiacSR,
  title={Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction.},
  author={Donald M. Bers},
  journal={Annual review of physiology},
  year={2014},
  volume={76},
  pages={107-27}
}
Synchronized SR calcium (Ca) release is critical to normal cardiac myocyte excitation-contraction coupling, and ideally this release shuts off completely between heartbeats. However, other SR Ca release events are referred to collectively as SR Ca leak (which includes Ca sparks and waves as well as smaller events not detectable as Ca sparks). Much, but not all, of the SR Ca leak occurs via ryanodine receptors and can be exacerbated in pathological states such as heart failure. The extent of SR… CONTINUE READING