Cardiac sarcolemmal purity is essential for the verification of adenylate cyclase inhibition via A1-adenosine receptors

@article{Schtz1986CardiacSP,
  title={Cardiac sarcolemmal purity is essential for the verification of adenylate cyclase inhibition via A1-adenosine receptors},
  author={Wolfgang Sch{\"u}tz and Michael Freissmuth and Viktoria Hausleithner and Elisabeth Tuisl},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1986},
  volume={333},
  pages={156-162}
}
Inhibition of cardiae adenylate cyclase by adenosine receptor agonists was reinvestigated in a more homogeneous sarcolemmal vesicular preparation than used in a previous study. Microsomal particles obtained by differential centrifugation were further fractionated on a shallow density gradient of Percoll. Two populations of plasma membrane vesicles were partially resolved. Identical peaks were identified for adenylate cyclase activity and [3H]ouabain binding, whereas 5′-nucleotidase activity and… CONTINUE READING
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Cardiac effects of adenosine and adenosine analogs on guinea-pig atrial and ventricular preparations: Evidence against a role of cyclic AMP and cyclic GMP

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4 Excerpts

162 tion of catecholamine - induced increase in force of contraction in guinea pig atrial and ventricular heart preparation . Evidence against a cyclic AMP - and cyclic GMP - dependent effect

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