Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.

@article{Bround2012CardiacRR,
  title={Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.},
  author={Michael J. Bround and Parisa Asghari and Rich B Wambolt and Lubos Bohunek and Claire Smits and Marjolaine Philit and Timothy J Kieffer and Edward G. Lakatta and Kenneth R. Boheler and Edwin D. W. Moore and Michael F. Allard and James D Johnson},
  journal={Cardiovascular research},
  year={2012},
  volume={96 3},
  pages={372-80}
}
AIMS The molecular mechanisms controlling heart function and rhythmicity are incompletely understood. While it is widely accepted that the type 2 ryanodine receptor (Ryr2) is the major Ca(2+) release channel in excitation-contraction coupling, the role of these channels in setting a consistent beating rate remains controversial. Gain-of-function RYR2 mutations in humans and genetically engineered mouse models are known to cause Ca(2+) leak, arrhythmias, and sudden cardiac death. Embryonic stem… CONTINUE READING
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