Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin.

@article{Francia2007CardiacRT,
  title={Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin.},
  author={Pietro Francia and Adriano Salvati and Cristina Balla and Paola de Paolis and Erika Pagannone and Marina Borro and Giovanna Gentile and Maurizio Simmaco and Luciano De Biase and Massimo Volpe},
  journal={European journal of heart failure},
  year={2007},
  volume={9 3},
  pages={306-9}
}
BACKGROUND Cardiac resynchronization therapy (CRT) has been introduced to treat drug refractory chronic heart failure (CHF). Apelin, the endogenous ligand of the APJ receptor, is under evaluation for its potential role in human CHF pathophysiology. This study aims to assess whether biventricular pacing affects plasma apelin levels in patients with severe CHF. METHODS AND RESULTS Fourteen patients (9 men, 5 women, mean age 68+/-13 years) undergoing biventricular pace-maker/ICD implantation… CONTINUE READING

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