Cardiac resident progenitor cells: evidence and functional significance.


It has been estimated that a serious myocardial infarction (MI) results in the loss of 1 billion functional cardiomyocytes, which are replaced with a fibrous scar, frequently leading to heart failure. Experimental data demonstrate that the mitotic renewal in the human myocardium exists but at a very low rate: 1% annually at the age of 25 and 0.45% at the… (More)
DOI: 10.1093/eurheartj/ehs208


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