Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction.

@article{Lucas1998CardiacRI,
  title={Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction.},
  author={David T Lucas and Luke I. Szweda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 2},
  pages={510-4}
}
Cardiac reperfusion and aging are associated with increased rates of mitochondrial free radical production. Mitochondria are therefore a likely site of reperfusion-induced oxidative damage, the severity of which may increase with age. 4-Hydroxy-2-nonenal (HNE), a major product of lipid peroxidation, increases in concentration upon reperfusion of ischemic cardiac tissue, can react with and inactivate enzymes, and inhibits mitochondrial respiration in vitro. HNE modification of mitochondrial… CONTINUE READING