Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells

@article{Weinberger2016CardiacRI,
  title={Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells},
  author={Florian Weinberger and Kaja Breckwoldt and Simon Pecha and Andrea Kelly and Birgit Geertz and Jutta Starbatty and Timur Alexander Yorgan and Kai-Hung Cheng and Katrin Lessmann and Tomas Ottemo Stolen and Marielle Scherrer-Crosbie and Godfrey I Smith and Hermann C. Reichenspurner and Arne Hansen and Thomas Eschenhagen},
  journal={Science Translational Medicine},
  year={2016},
  volume={8},
  pages={363ra148-363ra148}
}
Myocardial injury results in a loss of contractile tissue mass that, in the absence of efficient regeneration, is essentially irreversible. Transplantation of human pluripotent stem cell–derived cardiomyocytes has beneficial but variable effects. We created human engineered heart tissue (hEHT) strips from human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes and hiPSC-derived endothelial cells. The hEHTs were transplanted onto large defects (22% of the left ventricular wall, 35… CONTINUE READING
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Cardiovascular Regenerative Medicine

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