Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.

@article{Ye2014CardiacRI,
  title={Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.},
  author={Lei Ye and Ying-Hua Chang and Qiang Xiong and Pengyuan Zhang and Liying Zhang and Porur E Somasundaram and Mike Lepley and Cory Swingen and Liping Su and Jacqueline S Wendel and Jing Guo and Albert Jang and Daniel Rosenbush and Lucas V. Greder and James R Dutton and Jianhua Zhang and Timothy J Kamp and Dan S Kaufman and Ying Ge and Jianyi Jay Zhang},
  journal={Cell stem cell},
  year={2014},
  volume={15 6},
  pages={750-61}
}
Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute myocardial infarction (MI) to investigate the functional impact of intramyocardial transplantation of hiPSC-derived cardiomyocytes, endothelial cells, and smooth muscle cells, in… CONTINUE READING
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