Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing.

@article{Kuo2017CardiacRI,
  title={Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing.},
  author={Anderson H Kuo and Cun Li and Jinqi Li and Hillary F Huber and Peter W Nathanielsz and Geoffrey D Clarke},
  journal={The Journal of physiology},
  year={2017},
  volume={595 4},
  pages={1093-1110}
}
KEY POINTS Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short-term and long-term detrimental cardiomyopathies but differences between rodent and human cardiac physiology and placental-fetal development indicate a need for models in precocial species for translation to human development. We developed a baboon model for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac magnetic resonance… CONTINUE READING
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