Cardiac remodeling in a rat model of diet-induced obesity.

  title={Cardiac remodeling in a rat model of diet-induced obesity.},
  author={Andr{\'e} Soares Leopoldo and M{\'a}rio Matheus Sugizaki and Ana Paula Lima-Leopoldo and Andr{\'e} Ferreira do Nascimento and Renata de Azevedo Melo Luvizotto and Dijon Henrique Salom{\'e} de Campos and Katashi Okoshi and Maeli Dal Pai-Silva and Carlos Roberto Padovani and Ant{\^o}nio Carlos Cicogna},
  journal={The Canadian journal of cardiology},
  volume={26 8},
The mechanisms by which diet-induced obesity cause remodeling and cardiac dysfunction are still unknown. Interstitial collagen and myocardial ultrastructure are important in the development of left ventricular hypertrophy, and are essential to the adaptive and maladaptive changes associated with obesity. Thus, the accumulation of collagen and ultrastructural damage may contribute to cardiac dysfunction in obesity. The purpose of the present study was to investigate cardiac function in a rat… CONTINUE READING
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