Cardiac remodeling and contractile function in acid alpha-glucosidase knockout mice.

@article{Kamphoven2001CardiacRA,
  title={Cardiac remodeling and contractile function in acid alpha-glucosidase knockout mice.},
  author={Joep H. J. Kamphoven and Ren{\'e} Stubenitsky and Arnold J. J. Reuser and Ans T van der Ploeg and Pieter D. Verdouw and Dirk J. Duncker},
  journal={Physiological genomics},
  year={2001},
  volume={5 4},
  pages={171-9}
}
Pompe's disease is an autosomal recessive and often fatal condition, caused by mutations in the acid alpha-glucosidase gene, leading to lysosomal glycogen storage in heart and skeletal muscle. We investigated the cardiac phenotype of an acid alpha-glucosidase knockout (KO) mouse model. Left ventricular weight-to-body weight ratios were increased 6.3 +/- 0.8 mg/g in seven KO compared with 3.2 +/- 0.2 mg/g in eight wild-type (WT) mice (P < 0.05). Echocardiography under ketamine-xylazine… CONTINUE READING
11 Citations
29 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Similar Papers

Loading similar papers…