Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes.

@article{Tufan2012CardiacPC,
  title={Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes.},
  author={Hale Tufan and Xiu-feng Zhang and Nicole Haghshenas and Mark A Sussman and Lars Cleemann and Martin Morad},
  journal={Journal of molecular and cellular cardiology},
  year={2012},
  volume={53 5},
  pages={695-706}
}
Stem cell transplantation has been successfully used for amelioration of cardiomyopathic injury using adult cardiac progenitor cells (CPC). Engineering of mouse CPC with the human serine/threonine kinase Pim-1 (CPCeP) enhances regeneration and cell survival in vivo, but it is unknown if such apparent lineage commitment is associated with maturation of electrophysiological properties and excitation-contraction coupling. This study aims to determine electrophysiology and Ca(2+)-handling… CONTINUE READING

Similar Papers

Loading similar papers…