Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3

AIM Sphingosine-1-phosphate (S1P) is a cardioprotective agent. Signal transducer and activator of transcription 3 (STAT-3) is a key mediator of many cardioprotective agents. We aimed to explore whether STAT-3 is a key mediator in S1P-induced preconditioning. METHODS Langendorff-perfused hearts from Wistar rats and wild-type or cardiomyocyte-specific STAT… CONTINUE READING