Cardiac phosphoproteome reveals cell signaling events involved in doxorubicin cardiotoxicity.

Abstract

The successful use of anthracyclines like doxorubicin in chemotherapy is limited by their severe cardiotoxicity. Despite decades of clinical application, a satisfying description of the molecular mechanisms involved and a preventive treatment have not yet been achieved. Here we address doxorubicin-induced changes in cell signaling as a novel potential… (More)
DOI: 10.1016/j.jprot.2012.02.004

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