Cardiac phosphoproteome reveals cell signaling events involved in doxorubicin cardiotoxicity.


The successful use of anthracyclines like doxorubicin in chemotherapy is limited by their severe cardiotoxicity. Despite decades of clinical application, a satisfying description of the molecular mechanisms involved and a preventive treatment have not yet been achieved. Here we address doxorubicin-induced changes in cell signaling as a novel potential… (More)
DOI: 10.1016/j.jprot.2012.02.004


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