Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

@article{Harzheim2008CardiacPF,
  title={Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.},
  author={Dagmar Harzheim and K Holger Pfeiffer and Larissa Fabritz and Elisabeth Kremmer and Thorsten Buch and Ari Waisman and Paulus Kirchhof and Ulrich Benjamin Kaupp and Reinhard Seifert},
  journal={The EMBO journal},
  year={2008},
  volume={27 4},
  pages={692-703}
}
Important targets for cAMP signalling in the heart are hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels that underlie the depolarizing 'pacemaker' current, I(f). We studied the role of I(f) in mice, in which binding of cAMP to HCN4 channels was abolished by a single amino-acid exchange (R669Q). Homozygous HCN4(R669Q/R669Q) mice die during embryonic development. Prior to E12, homozygous and heterozygous embryos display reduced heart rates and show no or attenuated responses… CONTINUE READING

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