Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes.

@article{Ghelfi2008CardiacOS,
  title={Cardiac oxidative stress and electrophysiological changes in rats exposed to concentrated ambient particles are mediated by TRP-dependent pulmonary reflexes.},
  author={Elisa Ghelfi and Cl{\'a}udia Ramos Rhoden and Gregory A. Wellenius and Joy Lawrence and Beatriz Gonz{\'a}lez-Flecha},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={102 2},
  pages={328-36}
}
Previous studies suggest that, through the stimulation of pulmonary nervous endings, ambient particles modulate the autonomic tone on the heart leading to cardiac oxidant stress and dysfunction. In this paper we investigated the effect of blockade of vanilloid receptor 1 (Transient Receptor Potential Vanilloid Receptor 1 [TRPV1]) on concentrated ambient particles (CAPs)-induced cardiac oxidative stress and dysfunction in a rat model of inhalation exposure. Capsazepine (CPZ), a selective… CONTINUE READING

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