Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion.

@article{Hintz2003CardiacOO,
  title={Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion.},
  author={Kadon K. Hintz and David P. Relling and Jack T. Saari and Anthony J. Borgerding and Jinhong Duan and Bonnie H Ren and Kosai Kato and P N Epstein and Jun Ren},
  journal={Alcoholism, clinical and experimental research},
  year={2003},
  volume={27 7},
  pages={1090-8}
}
BACKGROUND Alcoholic cardiomyopathy is manifested as ventricular dysfunction, although its specific toxic mechanism remains obscure. This study was designed to examine the impact of enhanced acetaldehyde exposure on cardiac function via cardiac-specific overexpression of alcohol dehydrogenase (ADH) after alcohol intake. METHODS ADH transgenic and wild… CONTINUE READING