Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest

@article{Morgan2008CardiacOT,
  title={Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest},
  author={Sarah C. Morgan and Hyung-Yul Lee and Fr{\'e}d{\'e}ric Relaix and Lisa L Sandell and John M. Levorse and Mary R Loeken},
  journal={Mechanisms of Development},
  year={2008},
  volume={125},
  pages={757-767}
}
During neural tube closure, Pax3 is required to inhibit p53-dependent apoptosis. Pax3 is also required for migration of cardiac neural crest (CNC) from the neural tube to the heart and septation of the primitive single cardiac outflow tract into the aorta and pulmonary arteries. Whether Pax3 is required for CNC migration and outflow tract septation by inhibiting p53-dependent apoptosis is not known. In this study, mouse strains carrying reporters linked to Pax3 alleles were used to map the fate… CONTINUE READING
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Molecular basis of splotch and Waardenburg Pax - 3 mutations

  • W. Y. Chan, C. S. Cheung, K. M. Yung, A. J. Copp
  • Proc . Natl . Acad . Sci . USA
  • 2004
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