• Biology, Medicine
• Published in Circulation 2002
• DOI:10.1161/01.CIR.0000019516.31040.2D

Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes.

@article{Ashley2002CardiacNO,
  title={Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes.},
  author={Euan A. Ashley and Claire E. Sears and Simon M Bryant and Hugh C Watkins and Barbara Casadei},
  journal={Circulation},
  year={2002},
  volume={105 25},
  pages={
          3011-6
        }
}

• Euan A. Ashley, Claire E. Sears, +2 authors Barbara Casadei

BACKGROUND Evidence indicates that myocardial NO production can modulate contractility, but the source of NO remains uncertain. Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction. METHODS AND RESULTS Contraction was assessed in left ventricular myocytes isolated from mice with NOS1 gene disruption (NOS1(-/-) mice) and their… CONTINUE READING

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