Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves.

@article{Jain2011CardiacNC,
  title={Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves.},
  author={Rajan Jain and Kurt A. Engleka and Stacey L Rentschler and Lauren J. Manderfield and Li Li and Lijun Yuan and Jonathan A. Epstein},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 1},
  pages={422-30}
}
Congenital anomalies of the aortic valve are common and are associated with progressive valvular insufficiency and/or stenosis. In addition, aneurysm, coarctation, and dissection of the ascending aorta and aortic arch are often associated conditions that complicate patient management and increase morbidity and mortality. These associated aortopathies are commonly attributed to turbulent hemodynamic flow through the malformed valve leading to focal defects in the vessel wall. However, numerous… CONTINUE READING