Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications.

@article{Haddad2010CardiacMH,
  title={Cardiac myosin heavy chain gene regulation by thyroid hormone involves altered histone modifications.},
  author={Fadia H Haddad and Weihua Jiang and Paul W Bodell and Anqi X. Qin and Kenneth M. Baldwin},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 6},
  pages={H1968-80}
}
The antithetical regulation of cardiac α- and β-myosin heavy chain (MHC) genes by thyroid hormone (T(3)) is not well understood but appears to involve thyroid hormone interaction with its nuclear receptor and MHC promoters as well as cis-acting noncoding regulatory RNA (ncRNA). Both of these phenomena involve epigenetic regulations. This study investigated the extent that altered thyroid state induces histone modifications in the chromatin associated with the cardiac MHC genes. We hypothesized… CONTINUE READING

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BioEssays : news and reviews in molecular, cellular and developmental biology • 2009

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