Cardiac myosin binding protein-C: a structurally dynamic regulator of myocardial contractility

@article{Finley2014CardiacMB,
  title={Cardiac myosin binding protein-C: a structurally dynamic regulator of myocardial contractility},
  author={Natosha L Finley and Tzvia I. Cuperman},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2014},
  volume={466},
  pages={433-438}
}
Cardiac myosin binding protein-C (cMyBP-C) is a modular protein anchored to the thick filament through interactions mediated by its C-terminal region. The N-terminal region of cMyBPC-C regulates myocardial contractility by modifying actin-myosin association. Phosphorylation of the N-terminal region diminishes cMyBP-C’s capacity to regulate actin-myosin function. Despite a substantial body of literature, many issues remain unclear regarding the structural and functional roles of cMyBP-C. While… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
3 Citations
42 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Similar Papers

Loading similar papers…