Cardiac myofibrillogenesis inside intact embryonic hearts.

@article{Du2008CardiacMI,
  title={Cardiac myofibrillogenesis inside intact embryonic hearts.},
  author={Aiping Du and Jean M. Sanger and Joseph W. Sanger},
  journal={Developmental biology},
  year={2008},
  volume={318 2},
  pages={236-46}
}
How proteins assemble into sarcomeric arrays to form myofibrils is controversial. Immunostaining and transfections of cultures of cardiomyocytes from 10-day avian embryos led us to propose that assembly proceeded in three stages beginning with the formation of premyofibrils followed by nascent myofibrils and culminating in mature myofibrils. However, premyofibril and nascent myofibril arrays have not been detected in early cardiomyocytes examined in situ in the forming avian heart suggesting… CONTINUE READING
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