Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions.

@article{Gwechenberger1999CardiacMP,
  title={Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions.},
  author={M Gwechenberger and Leonardo H. Mendoza and Keith A. Youker and Nikolaos G Frangogiannis and Clifton Smith and Lloyd H. Michael and Mark L. Entman},
  journal={Circulation},
  year={1999},
  volume={99 4},
  pages={546-51}
}
BACKGROUND Previous work from our laboratory demonstrated that interleukin (IL)-6 plays a potentially critical role in postreperfusion myocardial injury and is the major cytokine responsible for induction of intracellular adhesion molecule (ICAM)-1 on cardiac myocytes during reperfusion. Myocyte ICAM-1 induction is necessary for neutrophil-associated myocyte injury. We have previously demonstrated the induction of IL-6 in the ischemic myocardium, and the current study addresses the cells of… CONTINUE READING
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Adhesion molecule induction and expression in neutrophil-induced myocardial injury

  • KA Youker, N Frangogiannis, M Lindsey, CW Smith, ML. Entman
  • Schwimmbeck P, eds. The Role of Immune…
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