Cardiac myocyte terminal differentiation. Potential for cardiac regeneration.

  title={Cardiac myocyte terminal differentiation. Potential for cardiac regeneration.},
  author={Soh Khum Tam and Wen-jie Gu and V. Mahdavi and Bernardo Nadal-Ginard},
  journal={Annals of the New York Academy of Sciences},
The exact mechanism of terminal differentiation in cardiac myocytes is currently unknown. Studies in the skeletal muscle system provided a model where muscle lineage termination gene directly interacts with Rb to produce and maintain the terminally differentiated state. This interaction provided the critical components for the lock in cell cycle arrest in skeletal muscle cell. Cardiac muscle appears on the surface very similar to skeletal muscle especially since they share large numbers of… CONTINUE READING

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