Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

  title={Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.},
  author={Yassine Sassi and A. Ahles and Dong-Jiunn Jeffery Truong and Y. Baqi and S. Lee and B. Husse and Jean-S{\'e}bastien Hulot and A. Foinquinos and T. Thum and C. M{\"u}ller and A. Dendorfer and Bernhard Laggerbauer and S. Engelhardt},
  journal={The Journal of clinical investigation},
  volume={124 12},
  • Yassine Sassi, A. Ahles, +10 authors S. Engelhardt
  • Published 2014
  • Biology, Medicine
  • The Journal of clinical investigation
  • Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained β-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure. [...] Key Result We report that infusion of cAMP into mice averted myocardial hypertrophy and fibrosis in a disease model of cardiac pressure overload. The protective effect of exogenous cAMP required adenosine receptor signaling.Expand Abstract
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