Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

@article{Sassi2014CardiacMC,
  title={Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.},
  author={Yassine Sassi and Andrea Ahles and Dong-Jiunn Jeffery Truong and Younis Baqi and Sang-yong Lee and Britta Husse and Jean-S{\'e}bastien Hulot and Ariana Foinquinos and Thomas Thum and Christa E. M{\"u}ller and Andreas Dendorfer and Bernhard Laggerbauer and Stefan Engelhardt},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 12},
  pages={
          5385-97
        }
}
Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained β-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure. Here, we have demonstrated that export of cAMP from cardiac myocytes is an intrinsic cardioprotective mechanism in response to cardiac stress. We report that infusion of cAMP into mice averted myocardial hypertrophy and fibrosis in a disease model of cardiac pressure overload… CONTINUE READING

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