Cardiac muscle cell cytoskeletal protein 4.1: Analysis of transcripts and subcellular location—relevance to membrane integrity, microstructure, and possible role in heart failure

Abstract

The spectrin-based cytoskeleton assembly has emerged as a major player in heart functioning; however, cardiac protein 4.1, a key constituent, is uncharacterized. Protein 4.1 evolved to protect cell membranes against mechanical stresses and to organize membrane microstructure. 4.1 Proteins are multifunctional and, among other activities, link integral… (More)
DOI: 10.1007/s00335-004-2436-7

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