Cardiac mitochondrial damage and inflammation responses in sepsis.

@article{Zang2007CardiacMD,
  title={Cardiac mitochondrial damage and inflammation responses in sepsis.},
  author={Qun S. Zang and David L. Maass and Sue Jean Tsai and Jureta W. Horton},
  journal={Surgical infections},
  year={2007},
  volume={8 1},
  pages={
          41-54
        }
}
BACKGROUND AND PURPOSE Studies in sepsis suggest that mitochondria mediate multiple organ dysfunction, including cardiac failure; however, the underlying molecular mechanisms remain elusive. This study examined changes in mitochondrial membrane integrity, antioxidant activities, and oxidative stress in the heart after infectious challenge (intratracheal Streptococcus pneumoniae, 4 x 10(6) colony-forming units). Inflammation responses also were examined. METHODS Cardiac tissues were harvested… CONTINUE READING
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