Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes

  title={Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes},
  author={Shali Chen and Prasanth Puthanveetil and Biao Feng and Scot J Matkovich and Gerald W. Dorn and Subrata Chakrabarti},
  booktitle={Journal of cellular and molecular medicine},
Diabetic cardiomyopathy is a cascade of complex events leading to eventual failure of the heart and cardiac fibrosis being considered as one of its major causes. miR-133a is one of the most abundantly expressed microRNAs in the heart. We investigated the role of miR-133a during severe hyperglycaemia. And, our aim was to find out what role miR-133a plays during diabetes-induced cardiac fibrosis. We saw a drastic decrease in miR-133a expression in the hearts of streptozotocin-induced diabetic… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 24 references

The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy

A Juan, JV Francisco
J Am Coll Cardiol • 2006
View 5 Excerpts
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