Cardiac mechanoenergetics in silico.

  title={Cardiac mechanoenergetics in silico.},
  author={M. Vendelin and Peter Bovendeerd and V. Saks and J. Engelbrecht},
  journal={Neuro endocrinology letters},
  volume={23 1},
The aim of this thesis is to investigate the link between biochemical intracellular processes and mechanical contraction of the cardiac muscle. First, the regulation of intracellular energy fluxes between mitochondria and myofibrils is studied. It is shown, that the experimentally observed metabolic stability of the cardiac muscle is reproducible by a simple feedback regulation mechanism, i.e., ATP consumption in myofibrils and ATP production in mitochondria are balanced by the changes of the… CONTINUE READING
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