Cardiac mechano-electric feedback: past, present, and prospect.

  title={Cardiac mechano-electric feedback: past, present, and prospect.},
  author={Peter Kohl and Ursula Ravens},
  journal={Progress in biophysics and molecular biology},
  volume={82 1-3},
Mechanical effects on heart rhythm have been known to the clinical community for well over a century, and documented cases include both arrhythmogenic and pro-rhythmic consequences of mechanical stimulation. The intracardiac pathway that leads from changes in the cardiac mechanical environment to altered electrical activity is referred to as mechano-electric feedback (MEF). Fundamental research into the mechanisms underlying cardiac MEF is 'engineering-intensive', and much of the current… CONTINUE READING