Cardiac iron across different transfusion-dependent diseases.

  title={Cardiac iron across different transfusion-dependent diseases.},
  author={John C. Wood},
  journal={Blood reviews},
  volume={22 Suppl 2},
Iron overload occurs in patients who require regular blood transfusions to correct genetic and acquired anaemias, such as beta-thalassaemia major, sickle cell disease, and myelodysplastic syndromes. Although iron overload causes damage in many organs, accumulation of cardiac iron is a leading cause of death in transfused patients with beta-thalassaemia major. The symptoms of cardiac iron overload will occur long after the first cardiac iron accumulation, at a point when treatment is more… CONTINUE READING