Cardiac ion channel trafficking defects and drugs.

  title={Cardiac ion channel trafficking defects and drugs.},
  author={Kathy C. G. de Git and Teun P de Boer and Marc A. Vos and Marcel A G van der Heyden},
  journal={Pharmacology & therapeutics},
  volume={139 1},
Fine control over the functional expression of cardiac ion channels is required to maintain normal action potential (AP) duration and QTc times. A growing number of drugs interfere with normal trafficking of ion channels to and from the plasma membrane, thereby altering the number of channels on the cell surface. Most drugs do this at clinically relevant concentrations, which may lead to potentially life-threatening cardiac arrhythmias. Recently, major progress has been made in the… CONTINUE READING

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