Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation

Abstract

After birth cardiomyocytes undergo terminal differentiation, characterized by binucleation and centrosome disassembly, rendering the heart unable to regenerate. Yet, it has been suggested that newborn mammals regenerate their hearts after apical resection by cardiomyocyte proliferation. Thus, we tested the hypothesis that apical resection either inhibits… (More)
DOI: 10.1038/s41598-017-08947-2

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Cite this paper

@inproceedings{Zebrowski2017CardiacIO, title={Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation}, author={David C. Zebrowski and Charlotte Harken Jensen and Robert P. Becker and Fulvia Ferrazzi and Christina Baun and Svend Hvidsten and S\oren Paludan Sheikh and Brian D. Polizzotti and Ditte Caroline Andersen and Felix B. Engel}, booktitle={Scientific reports}, year={2017} }