Cardiac immunoglobulin deposition in congenital heart block associated with maternal anti-Ro autoantibodies.

@article{Lee1987CardiacID,
  title={Cardiac immunoglobulin deposition in congenital heart block associated with maternal anti-Ro autoantibodies.},
  author={Lela A. Lee and Sally Coulter and S M Erner and Hai-yan Chu},
  journal={The American journal of medicine},
  year={1987},
  volume={83 4},
  pages={793-6}
}
Isolated congenital complete heart block is frequently found in offspring of mothers who have IgG anti-Ro/SSA autoantibodies. IgG deposition was reported in the heart of a baby who died from heart block and heart failure. The pattern of antibody deposition observed was the same as that reproduced in animal models for anti-Ro/SSA binding. The IgG deposition was present in, but not limited to, the conduction system. Scattered small infiltrates of mononuclear cells and a limited, patchy deposition… CONTINUE READING

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