Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen.

@article{Villarreal1992CardiacHC,
  title={Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen.},
  author={Francisco Joaqu{\'i}n. Villarreal and Wolfgang H. Dillmann},
  journal={The American journal of physiology},
  year={1992},
  volume={262 6 Pt 2},
  pages={
          H1861-6
        }
}
Cardiac hypertrophy induced by pressure overload is accompanied by increases in the deposition of extracellular matrix (ECM) proteins. We wanted to determine in this study whether changes in mRNA coding for transforming growth factor (TGF)-beta 1, TGF-beta 3, and the ECM proteins, fibronectin and collagen, occur during the early phases of cardiac hypertrophy. Steady-state mRNA levels were determined in sham-operated and thoracic-banded hypertrophied rat myocardium from 6 h to 30 days after… CONTINUE READING
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