Cardiac hypertrophy induced by prostaglandin F(2alpha) may be mediated by calcineurin signal transduction pathway in rats.

@article{Jiang2005CardiacHI,
  title={Cardiac hypertrophy induced by prostaglandin F(2alpha) may be mediated by calcineurin signal transduction pathway in rats.},
  author={Qing-song Jiang and Xie-nan Huang and Gui-zhong Yang and Zhi-kai Dai and Qi-xin Zhou and Jing-Shan Shi and Qin Wu},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2005},
  volume={57 6},
  pages={
          742-8
        }
}
In this paper, we studied the relationship between the prostaglandin F(2alpha) (PGF(2alpha))-induced cardiac hypertrophy and calcineurin (CaN) signal transduction pathway in vivo and in vitro. Male Sprague-Dawley rats were given a single i.p. injection with monocrotaline (MCT) (60 mg/kg) and then given orally with celecoxib (20 mg/kg) or vehicle once a day for 14 d before (from d 1 to d 14) or after (from d 15 to d 28) right ventricular hypertrophy (RVH) was formed. Body weight (BW), right… CONTINUE READING