Cardiac hypertrophy in spontaneously hypertensive rats.

@article{Sen1974CardiacHI,
  title={Cardiac hypertrophy in spontaneously hypertensive rats.},
  author={Subha Sen and Robert C. Tarazi and P. A. Khairallah and F M Bumpus},
  journal={Circulation research},
  year={1974},
  volume={35 5},
  pages={775-81}
}
Ventricular weight in spontaneously hypertensive rats (F26 generation, Okamoto-Aoki strain) was significantly higher (P < 0.001) than that in body weight-matched American Wistar and Kyoto-Wistar normotensive rats, not only among older groups of rats but also among younger groups that had not developed significant hypertension. Deoxyribonucleic acid (DNA) copcentration in ventricular muscle was not different from normal in the youngest group (P < 0.4) but was significantly reduced in the older… CONTINUE READING
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