Cardiac hormones target nuclear oncogenes c-Fos and c-Jun in carcinoma cells.

Abstract

BACKGROUND c-Fos is a cellular proto-oncogene which dimerizes with c-Jun proto-oncogene to form AP-1 transcription factor, which upregulates transcription of genes involved in proliferation and cancer formation. Four cardiac hormones, that is, long-acting natriuretic peptide (LANP), vessel dilator, kaliuretic peptide (KP) and atrial natriuretic peptide (ANP… (More)
DOI: 10.1111/eci.12153

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