Cardiac glycosides and intracellular Na+, K+, Ca2+.

  title={Cardiac glycosides and intracellular Na+, K+, Ca2+.},
  author={E. A. Noack},
  journal={Basic research in cardiology},
  volume={79 Suppl},
  • E. Noack
  • Published 1984
  • Biology
  • Basic research in cardiology
From the fact that cardiac glycosides exert their positive inotropy most likely via a concentration-dependent inhibition of the Na+/K+-activated ATPase, a membrane-bound enzyme regulating the intracellular potassium and sodium homeostasis, one might assume that intracellular electrolyte changes may be easily detectable. Just the opposite holds true. In the literature there are very conflicting observations depending on the experimental model, the analytical method used etc. At the moment… 
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