Cardiac glycosides and intracellular Na+, K+, Ca2+.

@article{Noack1984CardiacGA,
  title={Cardiac glycosides and intracellular Na+, K+, Ca2+.},
  author={E. A. Noack},
  journal={Basic research in cardiology},
  year={1984},
  volume={79 Suppl},
  pages={
          87-92
        }
}
  • E. Noack
  • Published 1984
  • Biology
  • Basic research in cardiology
From the fact that cardiac glycosides exert their positive inotropy most likely via a concentration-dependent inhibition of the Na+/K+-activated ATPase, a membrane-bound enzyme regulating the intracellular potassium and sodium homeostasis, one might assume that intracellular electrolyte changes may be easily detectable. Just the opposite holds true. In the literature there are very conflicting observations depending on the experimental model, the analytical method used etc. At the moment… 
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References

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It is generally agreed now that cardiac glycosides (CG) specifically react with the Na+-, K+-ATPase of the cardiac cell membrane, and it is supposed that such interaction is responsible for the toxic

Cardiac Na+, K+-adenosine triphosphatase inhibition by ouabain and myocardial sodium: a computer simulation.

It is concluded that a moderate sodium pump inhibition by inotropic concentrations of ouabain enhances the intracellular sodium transient but does not cause a significant myocardial sodium accumulation at normal heart rates.

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In the present work, an ATP-dependent Ca2+ transport system which can be conclusively ascribed to heart sarcolemma is described and it is shown that a heart vesicular preparation particularly enriched in sar colemma markers accumulates Ca2- in the presence of ATP.

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It is suggested that the sarcolemmal Ca2+ transport system may well be of significance in regulation of the contraction-relaxation cycle of cardiac muscle.

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Evidence will be presented to show that the rise in resting tension that is caused by an inadequate supply of oxygen involves a mobilization of Ca2+ from the internal stores, and insufficient ATP to drive the ATPase enzyme in the SR, rather than a malfunction of the enzyme.

Binding sites related to ouabain-induced stimulation or inhibition of the sodium pump

The existence of a binding with a higher affinity associated with the stimulation of the sodium pump is reported, in agreement with recent electrophysiological observations on Purkinje fibres showing that low doses of ouabain produce changes in the K gradient that reflect stimulation ofThe sodium pump.

Influence of Cardiac Glycosides on Electrolyte Exchange and Content in Cardiac Muscle Cells

In this present chapter, the experimental findings which have been published during the past decade (1970–1979) are intended to be focused on.

An analysis of the actions of low concentrations of ouabain on membrane currents in Purkinje fibres.

It is concluded that the changes in iK2 are solely attributable to changes in reversal potential, and it is suggested that ouabain may stimulate the Na+‐K+ exchange pump and so reduce the K concentration, [K]e, in the clefts of the preparation.

The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres

  • D. Ellis
  • Biology
    The Journal of physiology
  • 1977
The intracellular Na activity of sheep heart Purkinje fibres has been measured using recessed‐tip Na+‐sensitive glass micro‐electrodes with results comparable to that of animals treated with Na 2.1.