Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overload.

@article{Ruzicska2004CardiacGE,
  title={Cardiac gene expression of natriuretic substances is altered in streptozotocin-induced diabetes during angiotensin II-induced pressure overload.},
  author={Eva Ruzicska and G. Gilbert Foldes and Zolt{\'a}n Lak{\'o}-Fut{\'o} and Bal{\'a}zs S{\'a}rm{\'a}n and J{\'a}nos Wellmann and G{\'a}bor Sz{\'e}n{\'a}si and Zsolt Tulassay and Heikki Ruskoaho and Mikl{\'o}s T{\'o}th and Anik{\'o} Somogyi},
  journal={Journal of hypertension},
  year={2004},
  volume={22 6},
  pages={1191-200}
}
OBJECTIVE To gain insight into the cardiac adaptive mechanisms in diabetes, we studied whether angiotensin II (Ang II) alters expression of the atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and adrenomedullin (AM) genes in the left ventricle of the diabetic rat heart. METHODS Diabetes was induced by streptozotocin (STZ; 60 mg/kg body weight intravenously). During the last 24 h of 2.5 or 7 weeks of treatment of male Wistar rats with STZ or vehicle, Ang II (33 microg/kg per… CONTINUE READING