Cardiac gap junction channels: modulation of expression and channel properties.

Abstract

In the heart, intercellular gap junction channels constructed from connexin molecules are crucial for conduction of the electric impulse. Cardiomyocytes can be interconnected by channels composed of three types of connexin proteins: Cx40, Cx43 or Cx45. In mammalian hearts, these three isoforms are regionally differently expressed and even between the species differences exist. Each of these channel-types possesses specific properties and are susceptible to modulation by various mechanisms. In this paper we compare the differences in properties of these channels as deduced from studies on transfected cells and isolated cardiomyocytes and discuss the factors involved in modulation of channel properties. Next, we evaluate the consequences of alterations in expression and modulation of channel properties for cardiac function. Therefore, we have compared reports on genetically engineered animals and discuss this information in relation to various pathophysiological disorders.

Extracted Key Phrases

4 Figures and Tables

0100200300'03'05'07'09'11'13'15'17
Citations per Year

1,491 Citations

Semantic Scholar estimates that this publication has 1,491 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Veen2001CardiacGJ, title={Cardiac gap junction channels: modulation of expression and channel properties.}, author={Anouk van Veen and Harold Victor Maria van Rijen and Tobias Opthof}, journal={Cardiovascular research}, year={2001}, volume={51 2}, pages={217-29} }