Cardiac function and modulation of sarcomeric function by length.

  title={Cardiac function and modulation of sarcomeric function by length.},
  author={Laurin M. Hanft and Fredrick S Korte and Kerry S McDonald},
  journal={Cardiovascular research},
  volume={77 4},
The Frank-Starling relationship provides beat-to-beat regulation of ventricular function by matching ventricular input and output. This review addresses the subcellular mechanisms by which the ventricle adjusts its output (i.e. stroke volume) by changes in end-diastolic volume. The subcellular processes are placed in the context of the four phases of the cardiac cycle with emphasis on the sarcomeric properties that mediate the number of force-generating cross-bridges recruited during pressure… CONTINUE READING


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Myosin heavy chain dependence of the Frank-Starling relationship in rat working heart preparations

  • FS Korte, LM Hanft, KS. McDonald
  • Biophys J 2007;92:477a
  • 2007
1 Excerpt

Protein kinase C depresses cardiac myocyte power output and attenuates myofilament phosphorylation and mechanical responses induced by protein kinase A. (Abstract)

  • LM Hanft, FS Korte, KS. McDonald
  • Biophys J 2007;472a
  • 2007
1 Excerpt

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