Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.

@article{Seccia2003CardiacFO,
  title={Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.},
  author={Teresa Maria Seccia and Anna Sandra Belloni and Reinhold Kreutz and Martin Paul and Gastone Giovanni Nussdorfer and Achille Cesare Pessina and Gian Paolo Rossi},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={41 4},
  pages={666-73}
}
OBJECTIVES We investigated if endothelin (ET)-1 and the renin-angiotensin-aldosterone system play a role in cardiac fibrosis. BACKGROUND Angiotensin II (Ang II) can induce cardiac fibrosis, but the underlying mechanisms are incompletely understood. METHODS Four-week-old transgenic (mRen2)27 rat (TGRen2) received for four weeks a placebo, the mixed ET(A)/ET(B) endothelin receptor antagonist bosentan, the angiotensin II type I receptor (AT-1) antagonist irbesartan, the ET(A) endothelin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Traditional Cardiovascular Risk Factors for Incident Atrial Fibrillation.

Circulation journal : official journal of the Japanese Circulation Society • 2016

Endothelin-1 upregulation mediates aging-related cardiac fibrosis.

Journal of molecular and cellular cardiology • 2015
View 3 Excerpts

Similar Papers

Loading similar papers…