Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate.

@article{Hatano2009CardiacFH,
  title={Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate.},
  author={Noriyuki Hatano and Yuka Itoh and Katsuhiko Muraki},
  journal={Life sciences},
  year={2009},
  volume={85 23-26},
  pages={
          808-14
        }
}
AIMS Vanilloid type transient receptor potential channel (TRPV) could be a potential environmental sensor to multiple stimuli in many types of cells. In this study, we provide the first evidence of functional vanilloid type 4 transient receptor potential channel (TRPV4) in rat cardiac fibroblasts (CFs). MAIN METHODS Expression of TRPV4 in CFs was analyzed at mRNA and protein level. Function of TRPV4 in CFs was evaluated using a selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate… CONTINUE READING
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