Cardiac excitation–contraction coupling

@article{Bers2002CardiacEC,
  title={Cardiac excitation–contraction coupling},
  author={Donald M. Bers},
  journal={Nature},
  year={2002},
  volume={415},
  pages={198-205}
}
  • D. Bers
  • Published 10 January 2002
  • Biology, Physics
  • Nature
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important. It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation–contraction coupling. It is important to understand in quantitative detail exactly how calcium is moved around the various organelles of the myocyte in order to bring about excitation–contraction coupling if we are to understand the basic physiology of heart… 
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Excitation–Contraction Coupling in the Heart
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Experimental based multiscale computational models of excitation–contraction coupling in the cardiac myocyte and the insights that have been gained through their application are reviewed.
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The chapter explores the processes of excitation-contraction coupling (ECC) and calcium-induced calcium release (CICR) whilst appreciating the relevance of ECC in pathology and in engineering heart tissue.
DESIGN AND PHYSIOLOGY OF THE HEART | Cardiac Excitation–Contraction Coupling: Routes of Cellular Calcium Flux
The Sarcoplasmic Reticulum in the Vertebrate Heart
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The present review aims to update knowledge of the role of the SR in different vertebrates, and to discuss the underlying significance of this important organelle.
Ion Channels in the Heart.
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The major regionally determined electrical properties of these cardiac regions are reviewed and the available data regarding the molecular and ionic bases of regional cardiac function and dysfunction are presented.
Refilling Intracellular Calcium Stores.
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References

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