Cardiac excitation–contraction coupling
@article{Bers2002CardiacEC, title={Cardiac excitation–contraction coupling}, author={Donald M. Bers}, journal={Nature}, year={2002}, volume={415}, pages={198-205} }
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important. It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation–contraction coupling. It is important to understand in quantitative detail exactly how calcium is moved around the various organelles of the myocyte in order to bring about excitation–contraction coupling if we are to understand the basic physiology of heart…
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References
SHOWING 1-10 OF 105 REFERENCES
Excitation-Contraction Coupling and Cardiac Contractile Force
- Biology, MedicineDevelopments in Cardiovascular Medicine
- 2001
A large number of the cellular structures involved in E-C coupling, including myofilaments, are involved in cardiac contraction by SR and sarcolemmal Ca fluxes, and Ca inotropy and Ca mismanagement is studied.
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
- BiologyAmerican journal of physiology. Heart and circulatory physiology
- 2001
The VSRM is strongly modulated by phosphorylation and provides a new regulatory mechanism for cardiac contraction and is depressed in heart failure and may play an important role in contractile dysfunction.
Calcium release from cardiac sarcoplasmic reticulum.
- Biology, MedicineAnnual review of physiology
- 1982
Attention is focused on specific properties of the reticulum that are related to its integrated function within the cardiac cell, in particular the triggering mechanism for release of calcium from the Reticulum, changes in the properties of, during the cardiac cycle, and the modulation of sarcoplasmic Ca during a normal contraction of it myocardial cell.
Integrative Analysis of Calcium Cycling in Cardiac Muscle
- BiologyCirculation research
- 2000
This review illustrates how analysis of the control of calcium requires an integrated approach in which several systems are considered and predicts that, under some conditions, the above interactions can result in instability rather than ordered control of contractility.
Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart
- BiologyCurrent Biology
- 2000
Alterations of calcium-regulatory proteins in heart failure.
- Biology, MedicineCardiovascular research
- 1998
The control of calcium release in heart muscle.
- BiologyScience
- 1995
A unifying model for cardiac excitation-contraction coupling is developed that explains the large (but paradoxically stable) amplification of the trigger calcium influx by a combination of digital and analog behavior.
Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments.
- BiologyCirculation research
- 1998
Special features of the cardiac myofilament proteins that appear specialized for the unique functions of the heart are revealed, including their role in mechanical, chemical, and neurohumoral coupling processes that tune my ofilament activation to hemodynamics and beating frequency.
Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects.
- BiologyAmerican journal of physiology. Heart and circulatory physiology
- 1998
Neither PLB nor its phosphorylation are required for the CaMKII-dependent acceleration of the SS twitch [Ca]i decline and relaxation, and other quantitative aspects of Ca transport in WT and PLB-KO myocytes were also examined.