Cardiac energetics in daunorubicin-induced cardiomyopathy.

Abstract

Daunorubicin (DNR) was administered to one of each pair of litter mate rabbits at a weekly dosage rate of 40 mg/m2. Treated animals were killed when their pre-ejection period: left ventricular ejection time ratio (PEP:LVET) reached or exceeded 0.4. Mechanical, myothermic and polarographic measurements were made upon papillary muscles obtained from the right… (More)

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