Cardiac endothelium-myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction.

@article{Lim2015CardiacEI,
  title={Cardiac endothelium-myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction.},
  author={Shir Lynn Lim and Carolyn S. P. Lam and Vincent F M Segers and Dirk L. Brutsaert and Gilles W De Keulenaer},
  journal={European heart journal},
  year={2015},
  volume={36 31},
  pages={
          2050-2060
        }
}
Heart failure (HF) is an important global health problem with great socioeconomic burden. Outcomes remain sub-optimal. Endothelium-cardiomyocyte interactions play essential roles in cardiovascular homeostasis, and deranged endothelium-related signalling pathways have been implicated in the pathophysiology of HF. In particular, disturbances in nitric oxide (NO)-mediated pathway and neuregulin-mediated pathway have been shown to contribute to the development of HF. These signalling pathways hold… CONTINUE READING

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