Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats.

@article{Iwanaga1998CardiacEP,
  title={Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats.},
  author={Yoshitaka Iwanaga and Yukio Kihara and Hiroshi Hasegawa and Koichi Inagaki and Tohru Yoneda and Satoshi Kaburagi and Makoto Araki and Shigetake Sasayama},
  journal={Circulation},
  year={1998},
  volume={98 19},
  pages={
          2065-73
        }
}
BACKGROUND To investigate whether endogenous ET-1 participates in an adaptive process of left ventricular hypertrophy (LVH) or a maladaptive process from LVH to congestive heart failure (CHF), we used a Dahl salt-sensitive (DS) rat model, in which systemic hypertension caused compensated concentric LVH at the age of 11 weeks followed by marked LV dilatation and global hypokinesis at the age of 17 weeks. METHODS AND RESULTS By specific sandwich enzyme immunoassay, serum and myocardial ET-1… CONTINUE READING