Cardiac effects of injections of epinephrine into the spinal intermediolateral column.

@article{Malhotra1993CardiacEO,
  title={Cardiac effects of injections of epinephrine into the spinal intermediolateral column.},
  author={Vishal Malhotra and Anil Kachroo and Hreday N. Sapru},
  journal={The American journal of physiology},
  year={1993},
  volume={265 2 Pt 2},
  pages={H633-41}
}
Small doses of epinephrine (0.008, 0.05, and 0.1 pmol, i.e., 20-nl volumes of 0.40, 2.5, and 5 microM solutions) produced a dose-dependent increase in heart rate when micro-injected into the right intermediolateral column (IML) at T2 spinal level. These effects were mediated via alpha 1-adrenergic receptors because prazosin blocked them. The presence of alpha 1-adrenergic receptors at this site was confirmed by microinjections of phenylephrine (a specific agonist for these receptors… CONTINUE READING
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